Receptors. Proceedings of the 7th International Congress of Pharmacology, Paris, 1978

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Bibliography Conference papers and proceedings. Electronic books. Internet Resources. Summary Abstracts contains the abstracts of work presented at the 7th International Congress of Pharmacology: invited lectures, symposia, methodological seminars, and free communications.


The abstracts are organized in chronological order of presentation at the Congress. Some abstracts focus on chemistry and biochemistry of pituitary endorphins and their precursors; the biosynthesis and release of the enkephalins; enkephalin dynamics and neuronal localization; and physiological and pathophysiological relevance of the opiate receptors and their endogenous ligands. Other papers center on the mechanism. Mathematical modeling of corticosteroid pharmacogenomics in rat muscle following acute and chronic methylprednisolone dosing. Mol Pharm. Extracting global system dynamics of corticosteroid genomic effects in rat liver.

Gene Regulation and Systems Biology. Cancer Chem.

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Clin Pharmacokinet. Target-mediated pharmacokinetic and pharmacodynamic model of recombinant human erythropoietin rHuEPO. Context specific transcription factor prediction. Ann Biomed Eng. Microarray analysis of the temporal response of skeletal muscle to methylprednisolone: comparative analysis of two dosing regimens. Synergism between arsenic trioxide and heat shock protein 90 inhibitors on signal transducer and activator of transcription protein 3 activity--pharmacodynamic drug-drug interaction modeling.

Clin Cancer Res. Mathematical assessment of properties of precursor-dependent indirect pharmacodynamic response models. Assessment of dosing impact on intra-individual variability in estimation of parameters for basic indirect response models. Physiologically based pharmacokinetic modeling of FTY 2-amino-2[2- octylphenyl ethyl]propane-1,3-diol hydrochloride in rats after oral and intravenous doses. Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after intravenous and subcutaneous administration in rats..

Journal of Pharmacology and Experimental Therapeutics. Modeling circadian rhythms of glucocorticoid receptor and glutamine synthetase expression in rat skeletal muscle. Modeling glucocorticoid-mediated fetal lung maturation: I. Temporal patterns of corticosteroids in rat pregnancy. Modeling glucocorticoid-mediated fetal lung maturation: II.

Temporal patterns of gene expression in fetal rat lung. Assessment of basic indirect pharmacodynamic response models with physiological limits.. Pharmacodynamic models for agents that alter production of natural cells with various distributions of lifespans.. Endogenous histamine and cortisol levels in subjects with different histamine N-methyltransferase CT genotypes : a pilot study. Mol Diagn Ther. Corticosteroid-regulated genes in rat kidney: mining time series array data.

Stability of dexamethasone sodium phosphate in rat plasma. Int J Pharm. Temporal profiling of the transcriptional basis for the development of corticosteroid-induced insulin resistance in rat muscle.

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Assessment of drug interactions relevant to pharmacodynamic indirect response models. Interactions of prednisolone and other immunosuppressants used in dual treatment of systemic lupus erythematosus in lymphocyte proliferation assays. Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after single and multiple doses in healthy volunteers.

Modeling the metabolic effects of terbutaline in beta2-adrenergic receptor diplotypes. Clin Pharmacol Ther. The genomic response of skeletal muscle to methylprednisolone using microarrays: tailoring data mining to the structure of the pharmacogenomic time series. Stabilization and HPLC analysis of betamethasone sodium phosphate in plasma. Nucleic Acids Res. The influence of St. Gene arrays and temporal patterns of drug response: corticosteroid effects on rat liver.

Publications -- Alan M. Goldberg, PhD.

Funct Integr Genomics. Dose equivalency evaluation of major corticosteroids: Pharmacokinetics and cell trafficking and cortisol dynamics.

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Modeling of corticosteroid pharmacogenomics in rat liver using gene microarrays. Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after intravenous and subcutaneous dose administration in cynomolgus monkeys.

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Receptor-mediated pharmacokinetics and pharmacodynamics of interferon-beta 1a in monkeys. Comparative pharmacokinetics of coumarin anticoagulants L: Physiologic modeling of S-warfarin in rats and pharmacologic target-mediated warfarin disposition in man.

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Diversity of mechanism-based pharmacodynamic models. Drug Metab Disp. Integrated QSPR - pharmacodynamic model of genomic effects of several corticosteroids.

Krzyzanski W, Jusko WJ. Multiple-pool cell lifespan model of hematologic effects of anticancer agents. Chakraborty A, Jusko WJ. Pharmacodynamic interaction of recombinant human interleukin and prednisolone using in vitro whole blood lymphocyte proliferation. Pharmacokinetics and cell trafficking dynamics of 2-amino[2- 4-octylphenyl ethyl]propane-1,3-diol hydrochloride FTY in cynomolgus monkeys after single oral and intravenous doses. Fifth-generation model for corticosteroid pharmacodynamics: application to steady-state receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in rats.

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Pharmacodynamics and pharmacogenomics of methylprednisolone during 7-day infusions in rats. Wyska E, Jusko WJ. Semin Perinatol. Role of dosage regimen in controlling indirect pharmacodynamic responses. Adv Drug Deliv Rev. Indirect pharmacodynamic models for responses with multicompartmental distribution or polyexponential disposition. General pharmacokinetic model for drugs exhibiting target-mediated drug disposition. Pharmacodynamic modeling of time-dependent transduction systems. Developing compliance instructions for drug labeling. Modeling of dose-response-time data: four examples of estimating the turnover parameters and generating kinetic functions from response profiles.

Algorithm for application of Fourier analysis for biorhythmic baselines of pharmacodynamic indirect response models. Chronobiol Int. Modeling interactions between adrenal suppression and T-helper lymphocyte trafficking during multiple dosing of methylprednisolone. J Pharmacokinet Biopharm. Basic pharmacodynamic models for agents that alter production of natural cells.

Pharmacokinetic and pharmacodynamic interactions between dehydroepiandrosterone and prednisolone in the rat. Drug Metabol Drug Interact. Enhancement of tissue delivery and receptor occupancy of methylprednisolone in rats by a liposomal formulation. Methylprednisolone disposition in renal transplant recipients receiving triple-drug immunosuppression. Multiple-dose pharmacokinetics of imipramine and its major active and conjugated metabolites in depressed patients..

Pharmacokinetics of single and multiple doses of ethinyl estradiol and levonorgestrel in relation to smoking. The metyrapone test in schizophrenic patients and healthy subjects.. The metyrapone test in affective disorders and schizophrenia II. Changes upon treatment..